Survival Is Not the Only Valuable End Point in Melanoma Screening

The natural environment is valuable but not infinitely valuable

This article discusses the appeal to infinite value in environmental decision making. We argue that invoking infinite values as a means of faithfully representing the worth of certain parts of the natural environment is a mistake. Infinite values have a number of theoretical and practical problems associated with them. For example, we show that invoking infinite values makes it hard to motivate...

Do not underestimate nucleotide excision repair: It not only predicts melanoma risk but also survival outcome

Nucleotide excision repair (NER) removes UV-induced DNA damage and other bulky DNA lesions, thereby maintaining genomic integrity. Dr Qingyi Wei's group demonstrated over the last decade that NER fidelity and single-nucleotide polymorphisms (SNPs) in NER genes constitute melanoma risk biomarkers. In this issue, Li et al. provide evidence that SNPs in NER genes may also predict melanoma survival.

End-Point Variability Is Not Noise in Saccade Adaptation

When each of many saccades is made to overshoot its target, amplitude gradually decreases in a form of motor learning called saccade adaptation. Overshoot is induced experimentally by a secondary, backwards intrasaccadic target step (ISS) triggered by the primary saccade. Surprisingly, however, no study has compared the effectiveness of different sizes of ISS in driving adaptation by systematic...

a study of the rule ‘unforgivable in continuity (survival, sustainability) is not unforgivable in the beginning’

in islamic jurisprudence we face phrases such as ‘unforgivable in continuity (survival, sustainability) is not unforgivable in the beginning’ whose context suggest that this is considered by scholars as a known and accepted rule. but, after examining the traces of the phrase in the books of jurisprudence and rules of islamic jurisprudence, there seems to be no consensus as regards the authentic...

Only Female Age, and Not Blood Type, Is Associated with Ovarian Reserve